DNA Repair by the MRN Complex: Break It to Make It

DNA Repair by the MRN Complex: Break It to Make It

Genomic instability in ataxia telangiectasia-like disorder and Nijmegen breakage syndrome is due to disruption of the Mre11-Rad50-Nbs1 complex. Buis et al. (2008) and Williams et al. (2008) now reveal the importance of the nuclease activity of Mre11 for mammalian genome maintenance and present a molecular view of its active site.

Make It or Break It: Manipulating Robustness in Large Networks

The function and performance of networks rely on their robustness, defined as their ability to continue functioning in the face of damage (targeted attacks or random failures) to parts of the network. Prior research has proposed a variety of measures to quantify robustness and various manipulation strategies to alter it. In this paper, our contributions are twofold. First, we critically analyze...

DNA end resection machineries for human DNA break repair MRN constitute two − RPA − BLM − MRN and EXO 1 − RPA −

DNA Repair: Keeping It Together

A protein scaffold has been identified that holds a chromosome together in the event of a DNA double-strand break. This scaffold is dependent on Rad52 and the Rad50-Mre11-Xrs2 complex and withstands the pulling forces of the mitotic spindle during DNA damage checkpoint arrest.

Managing To Make It: Afterthoughts